MDSCs can differentiate into mature myeloid cells, such as tumor-associated macrophages (TAMs) and dendritic cells (DCs), as well as osteoclasts [9], fibroblasts [10], or phenotypes that activate CD8+ T cells through stimulator of interferon genes (STING)-dependent induction of type I interferons (IFNs) [11]. Here, CD8A is linked to neoplasm.