CNNM2 and pulmonary arterial hypertension: In addition, CNNM2 has also been implicated in the development of hypertension (Funato et al., 2017), intracranial aneurysm (Liu M. et al., 2023; Wu et al., 2024), myocardial infarction (Matsuoka et al., 2015), pulmonary hypertension (Wang et al., 2021), and sleep apnea (Gui et al., 2024).