Although a post hoc analysis controlling for age yielded robust results, it is important to consider other factors such as tumor location and volume, grade, IDH1 mutation, edema, and the use of antiepileptic drugs (Kesler et al., 2017; Kirkman et al., 2022; Tariq et al., 2023), which may influence cognitive outcomes. This evidence concerns the gene IDH1 and neoplasm.