PSAT1 also interacts with the codon 72 polymorphism of p53 (p5372p) competing with PPARγ coactivator-1α for binding to p5372p and thereby dissociating the former and activating oxidative phosphorylation and the TCA, whereas PSAT1 knockdown significantly reduced migration in hepatocellular carcinoma cells 55. This evidence concerns the gene PSAT1 and hepatocellular carcinoma.