In pancreatic cancer, under IL-6 stimulation, the cancer cells release exosomal FGD5-AS1, which is taken up by macrophages, where it can recruit p300 to promote STAT3-K685 acetylation, activate the STAT3/NF-κB signaling pathway, and mediate M2 polarization of macrophages (68). Here, STAT3 is linked to familial pancreatic carcinoma.