In esophageal carcinoma, exosomes derived from M2 macrophages can carry high levels of LncRNA AFAP1-AS1 into esophageal carcinoma cells to sponge miR-26a and promote the expression of ATF2, facilitating the migration, invasion, and lung metastasis of EC cells (113). The gene discussed is AFAP1; the disease is carcinoma of esophagus.