NFKB1 and immunodeficiency disease: Notably, when IKBKG affects T cells, it may coincide with the onset of inflammatory bowel disease, such as somatic mosaicism involving R175P, R182P, L227P, and Q348X35 in X-linked anhidrotic ectodermal dysplasia with immunodeficiency frequently lower NF-κB activity, thereby impacting antigen presentation, T cell differentiation, and function, leading to significant T cell infiltration of the intestinal wall.19