NFKB1 and immunodeficiency disease: In addition, NF-κB pathway can cause IP or anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID, OMIM 300291) when undergoes hypomorphic mutations in IKBKG; EDA-ID is an X-linked recessive inheritance often occurring in male,7 and its clinical manifestations encompass not only the aforementioned ectodermal dysplasia but also include immunodeficiency.