In addition, NF-κB pathway can cause IP or anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID, OMIM 300291) when undergoes hypomorphic mutations in IKBKG; EDA-ID is an X-linked recessive inheritance often occurring in male,7 and its clinical manifestations encompass not only the aforementioned ectodermal dysplasia but also include immunodeficiency. This evidence concerns the gene IKBKG and immune system disorder.