In addition, ovarian cancer stem cell markers (CD133 mRNA level and ALDH activity) were significantly increased in YWHAB knockdown cells versus control cells (Fig. 4B; n = 3; p < 0.001 and 0.01 for CD133 mRNA level in shYWHAB#1 and shYWHAB#2 cells, respectively; p < 0.001 for ALDH activity in both shYWHAB#1 and shYWHAB#2 cells; one-way ANOVA). The gene discussed is PROM1; the disease is ovarian carcinoma.