We further analyzed the differences in cellular features such as aging (Fig. S3F), EMT (Fig. S3G), cell migration (Fig. S3H), cell proliferation (Fig. S3I), PI3K/AKT/mTOR (Fig. S3J), PI3K/AKT activation (Fig. S3K), and PI3K/AKT signaling (Fig. S3L) between high and low ARS risk groups. The gene discussed is AKT1; the disease is Axenfeld-Rieger syndrome.