Although prior research has underscored EMP1’s involvement in glioma26 and glioblastoma20 via the PI3K/AKT mechanism, our study uniquely identifies EMP1 as an age-related factor that augments the oncogenic activities of PC via the PI3K/AKT pathway, both in vitro and in vivo. Here, AKT1 is linked to pachyonychia congenita.