A predictive Age-Related Score (ARS) system based on age-associated prognostic genes was developed, offering precise prognostic predictions for postoperative PC patients, which could be applied well at the single-cell level, showing diverse aging, epithelial–mesenchymal transition (EMT), cell migration, cell proliferation, and PI3K/AKT signaling activity in high and low ARS risk cells. Here, AKT1 is linked to pachyonychia congenita.