In this study, we identified a prognostic prediction model suitable for resectable PC patients and identified key age-related drivers of EMP1. In actual application, transcriptome sequencing or ARS gene expression panel detection can be performed on surgically resected PC tissues to predict postoperative patient survival and enable early intervention and timely adjustment of treatment regimens to ultimately prolong patient postoperative survival. The gene discussed is EMP1; the disease is pachyonychia congenita.