Our finding that B cell traits, Tregs panel, and one trait of CDC panel were linked with increased urolithiasis risk, including IgD-CD24-%lymphocyte, CD24 on transitional B cells, CD25 on IgD+ CD38-naïve, CD4 Treg% T cell, activated and resting Treg AC, and CD11c on myeloid DC. This evidence concerns the gene CD4 and urolithiasis.