CD4 and chronic myelogenous leukemia, BCR-ABL1 positive: In contrast, the proportion of CD8 TE cells was significantly increased in CML (p = 0.046), and the proportion of CD4 naïve cells was significantly decreased in CML (p = 0.032), which may indicate that CD8 TE and CD4 naïve cells are mainly involved in the CML immune microenvironment changes (Fig. 2D).