In summary, by analyzing paired single-cell TCR and T cell single-cell RNA profiles, we found that the expansion of CD8 TE cells in CML and a large number of differential genes in CD8 TE were enriched in important signaling pathways, indicating that CD8 TE cells may play an important role in CML. Here, CD8A is linked to chronic myelogenous leukemia, BCR-ABL1 positive.