Differential expression analysis was conducted to investigate the expression patterns of the five genes (XBP1, FBXO45, SAT2, AIFM1, and ACSL4) and eight other DEGs associated with ferroptosis (G3BP1, WBP11, TET2, IRF8, FASN, GDPD5, H1-4, and HUWE1) in both the pemphigus and control groups. This evidence concerns the gene IRF8 and pemphigus.