PRDX5 and Parkinson disease: ,65 PRDX6 has been found to be increased in the brain of PD patients,37 and other PRDXs, such as PRDX3 and PRDX5, have been reported to be found directly in LBs and suggested as potential direct interactors of α-syn oligomers,60,61 as well as localized to the lysosomal compartment.66