APEX2 and Parkinson disease: ,61 In accordance with our results, studies using proximity-dependent biotinylation proteomic screening, whether through antibody recognition or APEX2, have revealed that vesicular pathways, including exosomes, synaptic vesicles, and endocytic trafficking, directly interact with α-syn in tissue from PD patients and iPSC-derived neurons, emphasizing the relevance of our observations.36