TGFB1 and colorectal carcinoma: It has been demonstrated that Hippo/YAP interacts with several signaling pathways, including Wnt/β-catenin, TGF-β/Smad, Glut3/AMPK, Akt-mTOR, Notch, and MEK/ERK, to regulate CRC development and metastasis (Figure 4).