SAV1 and colorectal carcinoma: Conversely, miR-375-3p, which is often downregulated in CRC, directly targets YAP1 mRNA, and its restoration suppresses YAP expression and enhances chemosensitivity (64).Other miRNAs, such as miR-195, miR-22-3p, and miR-372-3p, modulate CRC progression by targeting YAP or its upstream regulators like SAV1 and LATS2 (104–106).