Furthermore, several studies suggest antidepressants alter the NFKB pathway and mTOR pathways, inducing apoptosis in glioblastoma cells through a variety of mechanisms.32,33 Several studies have shown that antidepressant treatment can decrease the invasiveness of glioblastoma and induce autophagy in others.34 Thus, some studies suggest that the suppression of these transcription factors that are highly associated with glioblastoma progression would be beneficial as adjuvant therapy in addition to standard of care. The gene discussed is MTOR; the disease is glioblastoma.