MFN2 and Charcot-Marie-Tooth disease type 2A1: However, MFN1 and MFN2 exhibit complementary functions in mediating mitochondrial tethering and fusion, providing valuable insights for the design of compounds capable of manipulating MFN1 conformations to treat CMT2A caused by MFN2 mutations (Detmer and Chan 2007; Ishihara et al.2004).