Nrf2 and Wnt/β-catenin signaling have been demonstrated to increase transcript and protein levels of multiple ABC transporter protein (including P-gp, MRP1 and ABCG2) and confer chemoresistance phenotype in various cancers (Kukal et al., 2021; Hemmati-Dinarvand et al., 2022; Cui et al., 2018; Kim et al., 2020). The gene discussed is PGP; the disease is cancer.