LDHA and human papilloma virus infection: Human papillomavirus infection triggered oxidative stress promotes the entry of LDHA into the nucleus, where LDHA exhibited a non-canonical enzyme activity to produce α-hydroxybutyrate from α-ketobutyrate and promoted histone H3K79 hypermethylation, followed by the activation of Nrf2-mediated antioxidant responses and Wnt/β-catenin pathway (Liu Y. et al., 2018).