Under oxidative stress, PKM2 has been found to translocate into mitochondria, where PKM2 interacts with BCL-2 and phosphorylates it at T69, preventing Cul3-based E3 ligase for BCL-2 degradation and consequent cell apoptosis in glioblastoma (Liang et al., 2017). The gene discussed is PKM; the disease is glioblastoma.