Moreover, active OXPHOS results in upregulation of P-gp/ABCB1, MRP1/ABCC1, MRP5/ABCC5, and BCRP/ABCG2 in cancer cells with p53 mutations or p53 allelic deletion, while the opposite phenomenon is observed in cells with wild type P53 (Belkahla et al., 2018). The gene discussed is ABCC5; the disease is cancer.