PGP and cancer: Moreover, active OXPHOS results in upregulation of P-gp/ABCB1, MRP1/ABCC1, MRP5/ABCC5, and BCRP/ABCG2 in cancer cells with p53 mutations or p53 allelic deletion, while the opposite phenomenon is observed in cells with wild type P53 (Belkahla et al., 2018).