On the one hand, FH deficiency causes the accumulation of oncometabolite fumarate that inactivates PTEN by directly reacting with PTEN at C211 to form S-(2-succino)-cysteine and ultimately sensitizes human type2 papillary renal cell carcinoma to sunitinib (Ge et al., 2022). This evidence concerns the gene PTEN and papillary renal cell carcinoma.