PKM and neoplasm: A recent study discovered a nuclear acetyl-CoA production system in which PKM2 and PDC constituted a complex to locally provide acetyl-CoA to acetyltransferase p300 for histone H3K9 acetylation at the gene enhancer, leading to the enhancement of AhR-mediated detoxification to chemotherapeutic drugs in tumor cells (Matsuda et al., 2016).