KAT2A and neoplasm: In addition to functioning as a metabolic enzyme in the TCA cycle, α-KGDH has been shown to localize in the nucleus, where it binds to acetyltransferase KAT2A in the promoter regions of target genes and subsequently facilitates KAT2A-mediated histone H3K79 succinylation, resulting in increased gene transcription, cell proliferation and tumor growth (Wang Y. et al., 2017).