STMN1, a microtubule-associated phosphoprotein, plays a pivotal role in HCC progression by modulating DNA methylation, regulating m6A RNA modification, and influencing disease-related immune responses, STMN1 serves as a key biomarker for HCC diagnosis and prognosis (Zhang E. D. et al., 2022). The gene discussed is STMN1; the disease is hepatocellular carcinoma.