For example, PPP1R12B has been demonstrated to act as a tumor suppressor in colorectal cancer (Zhou et al., 2008; Ding et al., 2019; Tan et al., 2022) and esophageal carcinoma (Chen et al., 2022), while paradoxically serving as an oncogenic factor in Wilms’ tumor (He et al., 2021) and breast cancer (Fokkelman et al., 2016). The gene discussed is PPP1R12B; the disease is colorectal cancer.