Notably, PPP1R12B acted as a tumor suppressor in colorectal cancer (Zhou et al., 2008; Ding et al., 2019; Tan et al., 2022) and esophageal cancer (Chen et al., 2022), but as an oncogenic factor in Wilms’ tumor (He et al., 2021) and breast cancer (Fokkelman et al., 2016). This evidence concerns the gene PPP1R12B and colorectal cancer.