PPP1R12B and Nephroblastoma: Notably, PPP1R12B acted as a tumor suppressor in colorectal cancer (Zhou et al., 2008; Ding et al., 2019; Tan et al., 2022) and esophageal cancer (Chen et al., 2022), but as an oncogenic factor in Wilms’ tumor (He et al., 2021) and breast cancer (Fokkelman et al., 2016).