ACHE and Cerebral cortical atrophy: Frontostriatal dysfunction could be monitored using targeted dopaminergic PET imaging (e.g., 18F-DOPA) (Burn et al., 1992) alongside CSF assays of synaptic dopamine turnover (LeWitt et al., 2011), whereas posterior cortical atrophy may be assessed via cholinergic PET tracers (e.g., 18F-FEOBV) (Saint-Georges et al., 2021) and CSF measures of acetylcholinesterase activity (Ruberg et al., 1986).