The N-terminal domain of PrP is an intrinsically disordered region, and intrinsically disordered proteins are able to undergo liquid-liquid phase separation, which can become aberrant in neurodegenerative disease.24 In vitro the prion protein variant Y145X spontaneously phase-separates into liquid droplets under physiological conditions, and these liquid-like condensates gradually mature into solid-like self-replicable amyloids. The gene discussed is PRNP; the disease is neurodegenerative disease.