POU4F1 and glioblastoma: Supporting this hypothesis, RTK2-CIMP was found to target genes essential for normal neuronal differentiation and function in neural precursors and tumors [75–78], including NEUROG1, TFAP2B, EBF1, and POU4F1. This finding was consistent with our deconvolution analysis of glioblastoma bulk RNA-seq data, which showed that neuronal cell types are absent in RTK2 tumors and that these cell types are almost exclusively associated with an astrocytic profile (AC-like), in which neural progenitor cell markers are generally expressed at low levels [66].