SOX10 and glioblastoma: We tested this hypothesis by knocking down Sox10 and analyzing CGI methylation, showing that SOX10 suppression in the mouse glioblastoma cell line mGB1 indeed resulted in RTK2-CIMP-like DNA hypermethylation (Wilcoxon test, P < 2.2e − 16) (Additional File 1: Fig S6A, B) and the OPC-to-AC-like cell state transition (Additional File 1: Fig S6C, D).