Several studies have demonstrated that tumor-derived EVs play a key role in promoting lymphangiogenesis and lymphatic metastasis across several tumor types; for example, melanoma-derived EVscontaining nerve growth factor receptor can reinforce LN pre-metastatic niche formation and metastasis [8], and cervical squamous cell carcinoma-secreted EVs-miR-221-3p can be transferred into human lymphatic endothelial cells (HLECs) to accelerate lymphatic metastasis [9]. Here, NGFR is linked to neoplasm.