VEGFC and posterior cortical atrophy: Our results showed that VEGF-C mRNA or protein remained unchanged in both circPDLIM5-overexpressing or circPDLIM5-knockdown PCa cells (PC3 and 22RV1) (Supplemental Figs. 8A–D), suggesting thatlymphangiogenesis and LN metastasisinduced by EVs-circPDLIM5in PCa might occur in a manner independent of VEGF-C.