KRAS and pancreatic ductal adenocarcinoma: Interestingly, Luo et al. reported that KRAS mutant-driven SUMOylation can trigger the transmission of EV-packaged heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) to promote lymphangiogenesis and LN metastasis in pancreatic ductal adenocarcinoma [39].However, our MS results showed that the enrichment of hnRNPA1 by the circPDLIM5 probe was less than that by the control probe (Sup Table 8).