Interestingly, a strong correlation was found after 7-day treatment with the DNMT1-specific inhibitor GSK5032 in ALL-SIL, LOUCY and JURKAT but not after 3 days (LOUCY and JURKAT), despite observing almost comparable levels of DNA demethylation to those at 7 days (Fig. 1D), suggesting that, in isolation of other mechanisms, only sustained DNA demethylation could impact cell viability. Here, DNMT1 is linked to acute lymphoblastic leukemia.