PAX5 and acute lymphoblastic leukemia: Interestingly, the T-ALL specific TSG TET2 [5, 19], as well as FBLN2 and PAX5, which have been shown to be hypermethylated and implicated in ALL malignancy [26–28], were upregulated in LOUCY cells in response to HMA treatment and were defined as methylation-sensitive (Fig. 3A, B).