FZD7, as a canonical receptor of the WNT pathway, has been proven to promote the development of pluripotent stem cells and to regulate therapy resistance in multiple cancer types [25–27].This study confirmed that KIAA1429 maintains the stability of FZD7 in a m6A-dependent manner to promote oxaliplatin resistance in CRC. The gene discussed is VIRMA; the disease is colorectal carcinoma.