PGD and neoplasm: To explore how the non-metabolic activity of 6PGD regulates CRC tumor growth and migration, we performed RNA-seq based on the knockdown of 6PGD, 6PGD inhibitor treatment, 6PGD wildtype and 6PGD K76R samples, and found that 6PGD serves a function in the cell cycles and migration that is independent of enzyme activity.