In addition, we confirmed that m6A modification on MDM2 mRNA was decreased in the CRC cells with the exogeneous expression of ALKBH5 was analyzed by MeRIP-qPCR assays (Fig. 6C); this induced the decreased expression of MDM2, HMGA2, and CCNA2, while increasing the expression of p53 (Fig. S6G), as well as the protein stability of p53 (Fig. S6H). Here, MDM2 is linked to colorectal carcinoma.