ALKBH5 and colorectal carcinoma: In addition, we confirmed that m6A modification on MDM2 mRNA was decreased in the CRC cells with the exogeneous expression of ALKBH5 was analyzed by MeRIP-qPCR assays (Fig. 6C); this induced the decreased expression of MDM2, HMGA2, and CCNA2, while increasing the expression of p53 (Fig. S6G), as well as the protein stability of p53 (Fig. S6H).