PGD and colorectal carcinoma: We found that the knockdown of endogenous 6PGD significantly enhanced the sensitivity to chemotherapy treatments, including 5-FU and oxaliplatin (Fig. 7A and 7B, Fig. S7A), while the targeting of 6PGD by Physicion does not significantly increase the sensitivity of CRC cells to chemotherapeutic drugs (Fig. S7B).