TP53 and squamous cell carcinoma of penis: Penile squamous cell carcinomas with TP53 mutations are found to be associated with a higher risk of lymph node metastases and poorer prognosis, and recent studies have proposed use of p53 immunohistochemistry as a reliable surrogate marker to mutational analysis in penile SCC that can help clinicians to better define risk groups and refine treatment strategies [29].