NLRC5 and viral infectious disease: Given that NLRC5 has been reported to shuttle between the cytoplasm and nucleus in HeLa cells [38] and that IFITM3 has been shown to facilitate the trafficking of incoming viral particles to lysosomes for degradation to inhibit viral infection [46, 47], we further investigated the possibility that IFITM3 mediates NLRC5 trafficking in SCLC cells.