AKT1 and neoplasm: Additionally, RV reversed the LPA-induced suppression of LC3-II accumulation and epithelial-mesenchymal transition (EMT) in SKOV3 (TP53-null) ovarian cancer cells, evident by restored LC3 puncta and E-cadherin re-expression [70].Through inhibition of the Akt/mTOR pathway, resveratrol triggers autophagy, restricting hsBAFF-driven growth and survival in primary murine B lymphocytes and Raji tumor cells; it promotes autophagic flux by enhancing autophagosome formation, upregulating ATG5 and LC3-II, and reducing p62 levels [71] (Table 1).