ACSL4 and gastric cancer: In gastric cancer (GC) cells, Zheng et al. showed that curcumin increased ATG5, ATG7, Beclin1, LC3B, and modulated ferroptosis through iron, MDA, ACSL4, and reduced SLC7A11 and GPX4, while suppressing the PI3K/AKT/mTOR pathway [103].