AGT and cardiac hypertrophy: In addition, cardiomyocyte Cdc42 deficiency significantly reduced AngII-induced cardiac hypertrophy and decreased heart weight (HW) and body weight (BW) (Fig. 1G and H), although there were no significant differences in AngII-induced increases in systolic/diastolic pressure or heart rate (Supplementary Figure S2B-D) between Cdc42CKO mice and Cdc42loxP/loxP mice.