Conversely, Maillet et al. observed the protective role of Cdc42 in cardiac hypertrophy via JNK activation in heart tissues in a TAC model since TAC-induced cardiac hypertrophy was exacerbated in mice with cardiac-specific Cdc42 deletion, which strongly expresses αMHC-Cre [15]. The gene discussed is MAPK8; the disease is cardiac hypertrophy.