To study the epigenetic regulation of TEs by CMEs in a cancer cell type-specific manner and in the context of p53, we utilized three cancer cell lines derived from colon, esophageal and prostate, where either high somatic retrotransposition events as in esophageal and colon cancers25 or TEs co-opted as oncogenic enhancers have been reported for example in prostate and colon cancers5,26. The gene discussed is TP53; the disease is digestive system cancer.