FTL and hereditary hyperferritinemia with congenital cataracts: Hyperferritinemia/cataract syndrome (HHCS) is caused by mutations (e.g. NM_000146.4:c.-164C  >  T) in the IRE in the 5′UTR of the L-ferritin (FTL) gene, preventing interaction with the IRPs and leading to dysregulated high levels of L-ferritin production [49].