For example, variants within a 7 bp region of the COL4A1 3′UTR (e.g. NM_001845.6:c.*31G > T) abolish a binding site for the miR-29 miRNA, leading to increased levels of COL4A1 mRNA and leading to cerebral small vessel disease [59]. The gene discussed is COL4A1; the disease is cerebral small vessel disease.