For the diagnosis of late-stage PC, CEMIP again exhibited the highest diagnostic accuracy (90.1%) at a cutoff point of > 5.70 ng/ml, compared to CEA, which had an accuracy of 72.2% at a cutoff point of > 9 ng/ml, and CA19-9, which demonstrated an accuracy of 66.3% at a cutoff point of > 34.56 ng/ml. This evidence concerns the gene CEACAM5 and pachyonychia congenita.