In line with that, gene expression analysis of a two-dimensional (2D) AD skin model showed an upregulation of skin barrier molecules such as filaggrin and loricrin by the plant extract and downregulation of AD typical inflammatory markers such as carbonic anhydrase 2 (CA2), CC-chemokine ligand (CCL)26 and IL-2428. The gene discussed is LORICRIN; the disease is Alzheimer disease.