Molecular dynamics (MD) simulations were performed over a 100 ns trajectory to validate the molecular docking findings and evaluate the dynamic stability of quinazolinone derivative 5 in complex with five critical cancer-related receptors: Topoisomerase II (5ZAD), VEGFR2 (3WZE), c-Met (3U6I), EGFR (1M17), and Estrogen Receptor α (ERα; 3ERT). This evidence concerns the gene KDR and cancer.