However, constitutive A1R expression leads to a loss of the ‘stem-like’ memory population (CD45RO−CD45RA+CD62L+CD27+) and reduces the persistence of CAR T cells in vivo limiting overall therapeutic efficacy, which is consistent with previous studies that have shown that less differentiated CAR T cells have greater self-renewal capacity and ability to mediate anti-tumor control2,33–36. Here, SELL is linked to neoplasm.