Analysis of spleens, tumors and draining lymph nodes (dLN) at day 7 post therapy showed that although tumor infiltrating A1R CAR T cells exhibited a more effector phenotype as demonstrated by increased expression of granzyme B (p = 0.06), Tim-3 and PD-1 (Supplementary Fig. 3A), CAR T cell numbers were significantly reduced relative to control CAR T cells within the spleen and tumor (Fig. 2B). Here, HAVCR2 is linked to neoplasm.