Following coculture with E0771-Her2 tumor cells, A1R CAR T cells exhibited significantly increased production of IFNγ and TNF (Fig. 1F) and increased expression of effector related genes PD-1 (Pdcd1), TIM-3 (Havcr2), Gzmb and Irf4 compared to control and A3R CAR T cells (Fig. 1G). The gene discussed is IRF4; the disease is neoplasm.