We also observed significant upregulation of genes encoding components of the NFAT/AP-1 signaling pathway heterodimers Junb and Fos, as well as NFAT associated transcription factors Egr1 and Egr2, and Tox in both unstimulated and tumor stimulated A1R CAR T cells47–49 (Supplementary Fig. 2E). This evidence concerns the gene JUN and neoplasm.