S1PR1 and neoplasm: Comparing significant DEGs between mouse and human A1R CAR T cells stimulated by tumor cells showed a high level of overlap cross-species, with A1R significantly reducing expression of memory markers S1PR1 or TCF7, while increasing expression of dual specificity phosphatases (DUSP2/5), EGR1, granzymes and cytokines (Supplementary Fig. 2F–G).