NR4A2 and neoplasm: Indeed, further analysis of tumor infiltrating T exhausted (Tex; PD-1HITCF-1−), T progenitor exhausted CD62L+/−(Tpex; PD-1INT/LOWTCF-1 + ) and T effector (Teff; PD-1INT/LOWTCF-1−) subsets (Supplementary Fig. 7C) revealed a significant increase in Teff subsets and a corresponding decrease in both CD62L+ and CD62L− Tpex subsets (Figs. 4L, and Supplementary Fig. 7D) in NR4A2/hA1R engineered CAR T cells, while no significant change in memory subsets were observed in the spleen34.