Specifically, 22Rv1-RR cells are larger, with increased circularity, roundness, and solidity, while displaying reduced skewness (Supplementary figure 7C–H), further supporting that RT-induced AR-STAT3-MUC1-MUC1-C axis drives cell plasticity and aggressiveness in advanced PCa. The gene discussed is STAT3; the disease is posterior cortical atrophy.