CLL-1, also known as CLEC12A, myeloid inhibitory c-type lectin-like receptor,235 dendritic cell-associated C-type lectin 2 (DCAL-2),236 or CD371, is a C-type lectin-like type II transmembrane receptor with a role in cell adhesion and cell-to-cell signaling.237–239 It is expressed in over 85% of patients with AML, both in blasts and LSCs.235,240 Furthermore, it is expressed exclusively in myeloid lineage cells198 and is absent in granulocyte-macrophage progenitors. This evidence concerns the gene CLEC12A and acute myeloid leukemia.