Specifically, STAR-T cells have demonstrated superior killing in low neoantigen density context and improved tumor control in mouse models in comparison with conventional CAR-T strategies.351,352 However, in contrast to CAR-T cells, most TCR-engineered T cells can only recognize intracellular tumor antigens presented by MHC molecules.353,354 Of note, CAR antigen sensitivity may also be enhanced without a structural modification by amplifying downstream activation signaling.355. The gene discussed is HLA-C; the disease is neoplasm.