,36,45 GWAS have identified significant single-nucleotide variations (SNVs) at the LPA locus on chromosome 6q26–27, specifically rs3798220 and rs10455872, which are strongly and independently associated with both Lp(a) levels and CAD risk.46, 47, 48 Moreover, it has been shown that the heritability of Lp(a) levels is remarkably high, estimated to be between 70% and 90%, primarily influenced by SNVs in the LPA gene and copy number variations in the K-IV type 2 domain.37 The gene discussed is LPA; the disease is coronary artery disorder.