Non-PTH-mediated hypercalcemia is most often associated with malignancies including multiple myeloma, although other causes, such as sarcoidosis, tuberculosis, endocrine disorders (e.g., adrenal insufficiency and pheochromocytoma), drug-induced hypercalcemia, vitamin D supplementation, and familial hypercalcemia, should also be considered (3). This evidence concerns the gene PTH and endocrine system disorder.