Conspicuously, a CD34-negative AML sample displayed multiple CD45E isoglycoforms (CD45RABC-E, CD45RBC-E, and CD45RB-E), indicating a shift in CD45 isoforms commensurate with its maturation (i.e., shifting away from CD45RABC-E as occurs across differentiation of oligopotent progenitors to more mature myeloid leukocytes). The gene discussed is PTPRC; the disease is acute myeloid leukemia.