In a glucose tolerance test performed at 11 months of age, APP/PS1/Hif-p4h-2gt/gt mice showed improved glucose clearance from blood compared with APP/PS1/Hif-p4h-2wt/wt (Fig. 3A), and they had lower fasting insulin levels and insulin resistance scores (Fig. 3B). Here, PSEN1 is linked to Insulin resistance.