Recently, the importance of HIF1α in regulating astrocytic glycolysis was highlighted in connection to AD pathology because of activation of indoleamine-2,3-dioxygenase 1 and increased kynurenine levels where indoleamine-2,3-dioxygenase 1 inhibition restored HIF-mediated glycolysis and homeostasis (38). Here, IDO1 is linked to Alzheimer disease.