CALCR and Anorexia: As the effect of cagrilintide on neuronal activation of ARC neurons was not assessed in this study, we cannot speculate on the implication of AgRP or POMC neurons in mediating anorexia or body weight loss.16, 17, 18 Nevertheless, we have previously shown that CTR signalling in POMC neurons is necessary for the maintenance of energy balance though the control of energy expenditure.16