PROCR and cutaneous mastocytosis: The relative importance of these cells and inflammatory factors and other reported aspects of CM pathogenesis, including IE adherence, endothelial activation, loss of endothelial protein C receptor, and CD8 + T cell migration and accumulation in the brain [2,32,35,49,60,68–70], should be addressed to better characterize the multifactorial nature of CM development [32].