For instance, Jantrapirom et al. demonstrated that liraglutide, another GLP-1 receptor agonist, restored the phosphorylation states of IRS1, Akt, and GSK-3β, while also reducing beta-amyloid accumulation and tau hyperphosphorylation in a human neuroblastoma cell line [29]. The gene discussed is IRS1; the disease is neuroblastoma.