A recent paper exploring the proteomic changes in microglia with another LSD, Batten disease caused by loss of CLN3, identify similar changes to those seen here, including increased TTYH3, PTTG1IP, LAMTOR3, PSAP, STARD3NL, TSPAN7, TMEM192 and NPC1 [86]. Here, CLN3 is linked to juvenile neuronal ceroid lipofuscinosis.