Consequently, genetic blockade of the CDSP pathway upon deletion of the Mb21d1 gene, encoding CGAS, imparted considerable salubrious phenotypic effects by prolonging survival, improving cardiac function, reducing cell death, and attenuating myocardial fibrosis, which are the cardinal features of DSP cardiomyopathy. Here, SLC22A5 is linked to Myocardial fibrosis.