Consistent with the attenuation of cardiac dysfunction in the Myh6-McmTamDspfl/flMb21d1–/– mice, transcript levels of several heart failure biomarkers, composed of those regulated by IRF3 and NF-κB transcription factors, were attenuated upon deletion of Mb21d1 gene in the Myh6-McmTamDspfl/flMb21d1–/– mouse model of DSP cardiomyopathy (Figure 7D). Here, IRF3 is linked to heart failure.