MYH6 and cardiomyopathy: We set out to determine whether the DDR pathways were activated and pathogenic in an established mouse model of desmoplakin (DSP) cardiomyopathy generated upon deletion of the Dsp gene in cardiomyocytes (Myh6-MerCreMerTam Dspfl/fl; Myh6-McmTamDspfl/fl).