Furthermore, the level of the endogenous CB1R agonist anandamide (AEA) was significantly increased in bronchoalveolar lavage fluid (BALF) of patients with IPF and HPSPF compared with their respective healthy controls, and it was negatively correlated with pulmonary function test parameters (2, 3). The gene discussed is CNR1; the disease is idiopathic pulmonary fibrosis.