To further explore the contribution of CB1R overactivity to the development of PF, we generated myeloid and AT2 cell–specific CB1R-KO mice as described in the Methods (Supplemental Figure 2A), then evaluated them for bleomycin-induced PF at 28 days after bleomycin (Figure 1A). The gene discussed is CNR1; the disease is pemphigus foliaceus.