POLQ and B-cell chronic lymphocytic leukemia: Consistent with our finding that cyclin D1 overexpression increases POLQ expression in cells, MCL primary cells exhibited the highest POLQ expression compared with other types of NHL, such as follicular lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, marginal zone lymphoma, and diffuse large B cell lymphoma, where cyclin D1 overexpression is not commonly observed (Figure 8B).