RCOR2 and cancer: By searching differentially expressed genes involved in interferon signaling pathways from our RNA-Seq dataset (Figure 4, A–D), we found that a family of MHC-II heavy chain genes and their transcriptional coactivator CIITA were repressed by RCOR2, which was validated in multiple cancer cell lines by RT-qPCR assay (Figure 4I and Supplemental Figure 4, D and E).