The RCOR2/LSD1 sub-axis suppresses RNF43 transcription to activate Wnt/β-catenin signaling in tumor cells, whereas the RCOR2/HDAC1/2 sub-axis inhibits CIITA and MHC-II expression in tumor cells to block activation of CD4+ and CD8+ T cells (Figure 9O). Here, RNF43 is linked to neoplasm.