RCOR2 KO significantly inhibited growth of MC38 colorectal tumors and TUBO mammary tumors in the syngeneic mouse models (Figure 2, C and D, and Supplemental Figure 1, A and B; supplemental material available online with this article; https://doi.org/10.1172/JCI188801DS1). This evidence concerns the gene RCOR2 and colorectal neoplasm.