SPARC and cancer: Briefly, IL-6 has been shown to induce apoptosis and inhibit proliferation in certain breast cancer subtypes [21]; OSM is associated with promoting cancer cell dormancy and reducing metastatic potential [22]; decorin interferes with tumor growth by modulating the tumor microenvironment and inhibiting receptor tyrosine kinases [23]; and SPARC plays a role in inhibiting tumor progression by regulating cell adhesion, migration, and extracellular matrix remodeling [24].