From a practical perspective, our findings are noteworthy, as regardless of the exercise mode, a single bout of exercise at moderate to high intensity can reduce the growth of MDA-MB-231 cells (i.e., triple negative cancer cells that lack hormone receptors and are therefore not expected to respond to hormonal fluctuations typically influenced by exercise) in survivors of breast cancer, potentially contributing to a lower risk of recurrence. This evidence concerns the gene NR4A1 and breast carcinoma.